Publications
Below are listed recent original publications. For older publications, or any further information please get in touch.
Abstract 4362146: Quantitative Myocardial Perfusion Assessment With Ultrafast Myocardial Contrast Echocardiography In Ischaemic Heart Disease – First in-human study.
Lasha Gvinianidze, MD MRCP, Matthieu Toulemonde, PhD, Reinette Hampson, MSc, Biao Huang, Biomedical Engineer, Gabriel Bioh, MBBS MRCP, Leigh-Ann Wakefield, MBChB MRCP, Sumantra Kumar De, MBBS MRCP, Emma Howard, MSc, Meng-Xing Tang, PhD, and Roxy Senior, MD DM FRCP
AHA Moderated Digital Poster Session
Contemporary review of stress echocardiography workforce within the UK: an EVAREST/BSE NSTEP study.
Willis J, Johnson CL, Krasner S, Woodward W, McCourt A, Dockerill C, Balkhausen K, Chandrasekaran B, Kardos A, Sabharwal N, Firoozan S, Sarwar R, Senior R, Sharma R, Wong K, Paton M, O’Driscoll J, Oxborough D, Pearce K, Robinson S, Yau AMW, Augustine DX, Leeson P; EVAREST/BSE-NSTEP Investigators.
Echo Res Pract. 2025 Oct 10;12(1):22. doi: 10.1186/s44156-025-00088-x. PMID: 41068862; PMCID: PMC12512890. https://pubmed.ncbi.nlm.nih.gov/41068862/
Multiphase Myocardial Microvascular Flow Dynamics Revealed by Transthoracic Ultrasound Localization Microscopy in HCM and Non-HCM Patients.
Huang B, Tonko J, Yan J, Smith CAB, Gvinianidze L, Toulemonde M, Hansen-Shearer J, Tan Q, Lambiase PD, Senior R, Tang MX
JACC Cardiovasc Imaging. 2025 Jul 23:S1936-878X(25)00311-0. doi: 10.1016/j.jcmg.2025.06.004. Online ahead of print.
Stress Echocardiography in Patients With Moderate or Severe Myocardial Ischemia: Insights From the ISCHEMIA Trial.
Picard MH, Saysana K, Cyr DD, Zeng X, Scherrer-Crosbie M, Shaw LJ, Senior R, Poh KK, Bangalore S, Leipsic JA, Mancini GJ, Budoff MJ, Hague CJ, Min JK, O’Brien SM, Hochman JS, Maron DJ, Reynolds HR; ISCHEMIA Research Group.
J Am Soc Echocardiogr. 2025 Jun;38(6):465-481. DOI: 10.1016/j.echo.2025.03.006
Invasive vs Conservative Management of Patients With Chronic Total Occlusion: Results From the ISCHEMIA Trial.
Sripal Bangalore, MD, MHA G.B. John Mancini, MD Jonathan Leipsic, MD Mathew J. Budoff, MD Yifan Xu, MPH Rebecca Anthopolos, DrPH Emmanouil S. Brilakis, MD, PhD Aeshita Dwivedi, MD John A. Spertus, MD, MPH Phil G. Jones, MS Yoon Joo Cho, MS Daniel B. Mark, MD, MPH Cameron J. Hague, MD James K. Min, MD Harmony R. Reynolds, MD Ahmed Elghamaz, MB, BCh Rajesh Goplan Nair, MD, DM Kreton Mavromatis, MD Gilbert Gosselin, MD Subhash Banerjee, MD Hristo Pejkov, MD, PhD Steven Lindsay, MB, BCh, MD J. Aaron Grantham, MD David O. Williams, MD Gregg W. Stone, MD Sean M. O’Brien, PhD Judith S. Hochman, MD David J. Maron, MD the ISCHEMIA Research Group
JACC. 2025 Apr, 85 (12) 1335–1349.https://doi.org/10.1016/j.jacc.2025.01.029
Quantitative Coronary Artery Plaque Parameters and Severity of Ischemia in Patients With INOCA.
Lerner JB, Pleasure M, Min JK, Picard MH, Peteiro J, Senior R, Celutkiene J, Shapiro MD, Pellikka PA, de Quadros AS, Chow BJW, Tamis-Holland JE, Rodriguez F, Fleg JL, Maron DJ, Hochman JS, Reynolds HR; CIAO-ISCHEMIA Research Group.
Circ Cardiovasc Imaging. 2025 Apr;18(4):e017367. doi: 10.1161/CIRCIMAGING.124.017367. Epub 2025 Mar 31.PMID: 40163030
Johnson CL, Krasner S, Woodward W, Mao E, McCourt A, Dockerill C, Balkhausen K, Chandrasekaran B, Kardos A, Sabharwal N, Firoozan S, Sarwar R, Senior R, Sharma R, Wong K, Augustine DX, Paton M, O’Driscoll J, Oxborough D, Pearce K, Robinson S, Willis J, Leeson P; EVAREST/BSE-NSTEP Investigators.
Eur Heart J Cardiovasc Imaging. 2025 Mar 22:jeaf099. doi: 10.1093/ehjci/jeaf099. Online ahead of print. PMID: 40119705
Picard MH, Saysana K, Cyr DD, Zeng X, Scherrer-Crosbie M, Shaw LJ, Senior R, Poh KK, Bangalore S, Leipsic JA, Mancini GJ, Budoff MJ, Hague CJ, Min JK, O’Brien SM, Hochman JS, Maron DJ, Reynolds HR; ISCHEMIA Research Group.
J Am Soc Echocardiogr. 2025 Mar 18:S0894-7317(25)00150-6. doi: 10.1016/j.echo.2025.03.006. Online ahead of print.PMID: 40112959
Woodward W, Johnson CL, Krasner S, O’Driscoll J, McCourt A, Dockerill C, Balkhausen K, Chandrasekaran B, Firoozan S, Kardos A, Sabharwal N, Sarwar R, Senior R, Sharma R, Wong K, Augustine DX, Leeson P.
Eur Heart J Cardiovasc Imaging. 2025 Jan 31;26(2):187-196. https://doi.org/10.1093/ehjci/jeae291
Reynolds HR, Page CB, Shaw LJ, Berman DS, Chaitman BR, Picard MH, Kwong RY, Min JK, Leipsic J, Mancini GBJ, Budoff MJ, Hague CJ, Senior R, Szwed H, Bhargava B, Celutkiene J, Gadkari M, Bainey KR, Doerr R, Ramos RB, Ong P, Naik SR, Steg PG, Goetschalckx K, Chow BJW, Scherrer-Crosbie M, Phillips L, Mark DB, Spertus JA, Alexander KP, O’Brien SM, Boden WE, Bangalore S, Stone GW, Maron DJ, Hochman JS; ISCHEMIA Research Group.
Circ Cardiovasc Interv. 2024 Dec;17(12):e013743. https://doi.org/10.1161/CIRCINTERVENTIONS.123.013743
Myocardial Ischaemia, Not Valve Hemodynamics, Determines Prognosis in Patients with Symptomatic Moderate Aortic Stenosis
Vamvakidou, A., Hampson, R., Singh, B., Evans, J., and Senior, R.
ACC March 2025: Abstract presentation
International Variation in Health Status Benefits in Patients Undergoing Initial Invasive Versus Conservative Management for Chronic Coronary Disease: Insights From the ISCHEMIA Trial
Nobuhiro Ikemura, John A Spertus, Dan Nguyen, Zhuxuan Fu, Philip G Jones, Harmony R Reynolds, Sripal Bangalore, Balram Bhargava, Roxy Senior, Ahmed Elghamaz, Shaun G Goodman, Renato D Lopes, Radoslaw Pracoń, José López-Sendón , Aldo P Maggioni, Shun Kohsaka, Gregory A Roth, Harvey D White, Kreton Mavromatis, William E Boden, Fatima Rodriguez, Judith S Hochman, David J Maron; ISCHEMIA Research Group.
Circulation: Cardiovascular Quality and Outcomes. 2024 Oct, Vole 17 (10). https://doi.org/10.1161/CIRCOUTCOMES.123.010534
Ultrafast myocardial contrast echocardiography for the assessment of coronary artery disease: First in- human.
Gvinianidze, L., Toulemonde, M., Hampson, R., Huang, B., Bioh, G., Wakefield, L., Patel, A., Rajan, K., Tang, MX., Senior, R.
Circulation: Cardiovascular Imaging. 2024 Oct. Vol 17 (10). https://doi.org/10.1161/CIRCIMAGING.124.0172
Senior R, Khattar RS.
JACC Cardiovasc Imaging. 2024 Aug 2:S1936-878X(24)00252-3. Online ahead of print. PMID: 39152962. DOI: 10.1016/j.jcmg.2024.06.014
ESC Scientific Document Group. 2024 ESC Guidelines for the management of chronic coronary syndromes.
Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, Banning AP, Budaj A, Buechel RR, Chiariello GA, Chieffo A, Christodorescu RM, Deaton C, Doenst T, Jones HW, Kunadian V, Mehilli J, Milojevic M, Piek JJ, Pugliese F, Rubboli A, Semb AG, Senior R, Ten Berg JM, Van Belle E, Van Craenenbroeck EM, Vidal-Perez R, Winther S;
Eur Heart J. 2024 Aug 30:ehae177. doi: 10.1093/eurheartj/ehae177. Epub ahead of print. PMID: 39210710. 2024 ESC Guidelines for the management of chronic coronary syndromes – PubMed (nih.gov)
Yan, J., Huang, B., Tonko, J., Toulemonde, M., Hansen-Shearer, J., Tan, Q., Riemer, K., Ntagiantas, K., Chowdhury, R.A., Lambiase, P. D., Senior, R. and Tang, M.
Transthoracic ultrasound localization microscopy of myocardial vasculature in patients. Nat. Biomed. Eng (2024). May.
Sidik, N., McEntegart, M., Joshi, F., Owens, C., Shaukat, A., Gallagher, S., Strange, J., Tang, K., Elghamaz, A., Mozid, A., Ladwiniec, A., Oldroyd, K., Schuette, D., Copt, S., and Spratt, J.
Safety and Effectiveness of a Novel Microcatheter in Coronary Chronic Total Occlusions – The BIOMICS Study. JSCAI. 2024. May
Gvinianidze, G., Toulemonder, M., Hampson, R., Wakefield, L., Bioh, G., Tang, M. and Senior, R.
Feasibility of High Frame Rate Contrast-Enhanced Ultrasound for the Assessment of Ischaemic Heart Disease in Humans. J Am Coll Cardiol. 2024 Apr, 83 (13_Supplement) 1430.
https://doi.org/10.1016/S0735-1097(24)03420-X
Harmony Reynolds, Derek Cyr, C. Noel Bairey Merz, Leslee Shaw, Bernard Chaitman, William Boden, Karen Alexander, Yves Rosenberg, Sripal Bangalore, Gregg Stone, Claes Held, John Spertus, Kaatje Goetschalckx, Olga Bockeria, Jonathan Newman, Jeffrey Berger, Ahmed Elghamaz, Renato Lopes, James Min, Daniel Berman, Michael Picard, Raymond Kwong, Robert Harrington, Boban Thomas, Sean O’Brien, David Maron, and Judith Hochman. ISCHEMIA Research Group.
Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients with Chronic Coronary Disease: Insights from the ISCHEMIA Trial. J Am Heart Assoc. 2024;13:e029850.
https://doi.org/10.1161/JAHA.122.029850
Nobuhiro Ikemura, John Spertus, Dan Nguyen, Zhuxuan Fu, Philip Jones, Harmony Reynolds, Sripal Bangalore, Balram Bhargava, Roxy Senior, Ahmed Elghamaz, Shaun Goodman, Renato Lopes, Radoslaw Pracon, Jose Luis Lopez-Sendon, Aldo Pietro Maggioni, Shun Kohsaka, Gregory Roth, Harvey White, Kreton Mavromatis, William Boden, Fatima Rodriguez, Judith Hochman, and David Maron; ISCHEMIA Research Group.
International Variation in Health Status Benefits in Patients Undergoing Initial Invasive Versus Conservative Management for Chronic Coronary Disease: Insights from the ISCHEMIA trial. J Am Coll Cardiol. 2023 Mar, 81 (8_Supplement) 1111.
https://doi.org/10.1016/S0735-1097(23)01555-3
Bioh, G., Botrous, C. & Senior, R.
Efficacy and safety of use of ultrasound enhancing agent in patients hospitalized with COVID-19. Int J Cardiovasc Imaging (2023).
Reinette Hampson, Roxy Senior , Liam Ring, Shaun Robinson, Daniel X Augustine, Harald Becher, Natasha Anderson, James Willis, Badrinathan Chandrasekaran, Attila Kardos, Anjana Siva, Paul Leeson, Bushra Rana, Navtej Chahal, David Oxborough.
Contrast echocardiography: a practical guideline from the British Society of Echocardiography. Echo Res Pract10, 23 (2023)
Johnson CL, Woodward W, McCourt A, Dockerill C, Krasner S, Monaghan M, Senior R, Augustine DX, Paton M, O’Driscoll J, Oxborough D, Pearce K, Robinson S, Willis J, Sharma R, Tsiachristas A, Leeson P; EVAREST/BSE-NSTEP Investigators
https://doi.org/10.1186/s44156-023-00020-1
Picano E, Pierard L, Peteiro J, Djordjevic-Dikic A, Sade LE, Cortigiani L, Van De Heyning CM, Celutkiene J, Gaibazzi N, Ciampi Q, Senior R, Neskovic AN, Henein M.
https://doi.org/10.1093/ehjci/jead250
Perera D, Ryan M, Morgan HP, Greenwood JP, Petrie MC, Dodd M, Weerackody R, O’Kane PD, Masci PG, Nazir MS, Papachristidis A, Chahal N, Khattar R, Ezad SM, Kapetanakis S, Dixon LJ, De Silva K, McDiarmid AK, Marber MS, McDonagh T, McCann GP, Clayton TC, Senior R, Chiribiri A; REVIVED-BCIS2 Investigators.
Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction: A Prespecified Secondary Analysis of the REVIVED-BCIS2 Trial. JAMA Cardiol. 2023 Oct 25
doi:10.1001/jamacardio.2023.3803
Davis EF, Crousillat DR, Peteiro J, Lopez-Sendon J, Senior R, et al CIAO-ISCHEMIA Research Group.
Global Longitudinal Strain as Predictor of Inducible Ischaemia in No Obstructive Coronary Artery Disease in the CIAO-ISCHEMIA Study. J AM Soc Echocardiography (2023) 37(1) 89-99
Gurunathan S, Shanmuganathan S, Chopra A, Pradhan J, Aboud L,Hampson R, Yakupoglu Y, Bioh G, Banfield A, Gage H,Khattar, Senior R
Comparative Effectiveness of Exercise Electrocardiography Versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study. Eur Heart J Open. 2023 May 22;3(3).
Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O’Brien SM, Boden WE, Chaitman BR, Senior R, López-Sendón J, Alexander KP, Lopes RD, Shaw LJ, Berger JS, Newman JD, Sidhu MS, Goodman SG, Ruzyllo W, Gosselin G, Maggioni AP, White HD, Bhargava B, Min JK, Mancini GBJ, Berman DS, Picard MH, Kwong RY, Ali ZA, Mark DB, Spertus JA, Krishnan MN, Elghamaz A, Moorthy N, Hueb WA, Demkow M, Mavromatis K, Bockeria O, Peteiro J, Miller TD, Szwed H, Doerr R, Keltai M, Selvanayagam JB, Steg PG, Held C, Kohsaka S, Mavromichalis S, Kirby R, Jeffries NO, Harrell FE Jr, Rockhold FW, Broderick S, Ferguson TB Jr, Williams DO, Harrington RA, Stone GW, Rosenberg Y; ISCHEMIA Research Group.
Initiall Invasive or Conservative Strategy for Stable Coronary Disease. N Engl J Med. 2020 Apr 9;382(15):1395-1407.
Fusco F, Shimada E, Scognamiglio G, Senior R, Gatzoulis MA, Babu-Narayan S, Li W. Restrictive ventricular septal defect resulting in systemic outflow obstruction in adults with Fontan circulation. Challenging diagnosis of a serious and potentially fatal complication.
J Cardiovasc Med 2020; 21(3): 276-279
Mushemi-Blake S, Surkova E, Hatipoqlu S, Senior R, Li W. Severe regurgitation of a double-orifice left atrioventricular valve in a patient with repaired atrioventricular septal defect: Added value of 3D echocardiography. Eur Heart J Cardiovasc Imaging 2020; 21(7): 814
Ahmadvazir S, Pradhan J, Khattar RS, Senior R. Long-Term Prognostic Value of Simultaneous Assessment of Atherosclerosis and Ischemia in Patients with Suspected Angina: Implications for Routine Use of Carotid Ultrasound During Stress Echocardiography
J Am Soc Echocardiogr 2020;33(5):559-569
Halliday B, Senior R, Pennell D
Assessing left ventricular systolic function – from ejection fraction to strain analysis
Eur Heart J 2020
Chahal N, Senior
Assessing Systolic Function In Aortic Stenosis: The Earlier The Better?
Heart 2020;106(16):1200-1201
Ahmadvazir S, Pradhan J, Khattar RS, Senior R
Sex-based impact of carotid plaque in patients with chest pain undergoing stress echocardiography. Heart 2020
Nam MCY, Meneses ML, Byrne CD, Richman T, Quah JX, Bailey TG, Hickman I, Anstey C, Askew CD, Senior R, Stanton T, Russell AW, Greave K. An experimental series investigating the effects of hyperinsulinemic euglycemia on myocardial blood flow reserve in healthy individuals and on myocardial perfusion defect size following st-segment elevation myocardial infarction. J Am Soc Echocardiogr 2020; ; 33:868
Reynold HR, Shaw LJ, Min JK, Spertus JA, Chaitman BR, Berman DS, Picard MH, Kwong RY, Bairey-Nerz CN, Cyr DD, Lopes DD, Lopez- Sendon JL, Held C, Szwed H, Senior R, Gosselin G, Nair R, Elghamaz A, Bockeria O, Chen J, Chemyavskiy AM, Bhargava B, Newman JD, Hinic SB, Jaroch J, Hoye A, Berger J, Boden WE, O’Brien SM, Maron DJ, Ischemia Research Group.
Association of sex with severity of coronary artery disease, ischemia, and symptom burden in patients with moderate or severe ischemia: secondary analysis of the ischemia randomized clinical trial. JAMA Cardiol. 2020 Jul 1;5(7):773-786
Dewey M, Siebes M, Kachelrieß M, Kofoed KF, Maurovich-Horvat P, Nikolaou K, Bai W, Kofler A, Manka R, Kozerke S, Chiribiri A, Schaeffter T, Michallek F, Bengel F, Nekolla S, Knaapen P, Lubberink M, Senior R, Tang MX, Piek JJ, van de Hoef T, Martens J, Schreiber L; Quantitative Cardiac Imaging Study Group.
Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia.
Nat Rev Cardiol 2020;17(7):427-450
Bioh G, Senior R.
Stress echocardiography in the era of fractional flow reserve
Current Cardiovascular Imaging Reports 2020; 13(6)
Danylenko O, Surkova E, Senior R, Li W
Unexpected mechanism of mitral regurgitation in a patient post ALCAPA repair: Added value of three-dimensional echocardiography
Echocardiography 2020; 37: 1315-1317
Senior R, Khattar RS
Assessment of aortic stenosis: Time to go with the flow
Editorial Coment: J Am Coll Cardiol 2020; 75 (15): 1770-1771
Radhakrishnan A, Price AM, Pickup LC, Law JP, McGee KC, Fabritz L, Senior R, Steeds RP, Ferro CJ, Townend JN
Coronary flow velocity reserve and inflammatory markers in living kidney donors
Int J Cardiol 2020 (in press)
Yakupoglu HY, Saeed S, Senior R, Baksi AJ, Lyon AR, Khattar RS. Reversible exercise induced left ventricular dysfunction in symptomatic patients with previous Takotsubosyndrome: insights from stress echocardiography.
Eur Heart J Cardiovasc Imaging. 2020 Sep 18: jeaa237. doi: 10.1093/ehjci/jeaa237. Online ahead of print
Gurunathan S, Shanmuganathan M, Hampson R, Khattar R, Senior R.
Role of adjuvant carotid ultrasound in women undergoing stress echocardiography for the assessment of suspected coronary artery disease.
Open Heart 2020 (in press)
Hochman JS, Reynolds HR, Bangalore S, O’Brien SM, Alexander KP, Senior R, Boden WE, Stone GW, Goodman SG, Lopes RD, Lopez-Sendon J, White HD, Maggioni AP, Shaw LJ, Min JK, Picard MH, Berman DS, Chaitman BR, Mark DB, Spertus JA, Cyr DD, Bhargava B, Ruzyllo W, Wander GS, Chernyavskiy AM, Rosenberg YD, Maron DJ; ISCHEMIA Research Group
Baseline Characterstics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial
JAMA Cardiol 2019; 4(3): 273-286
Chong A, Senior R, Wahi S.
Contemporary Imaging of Aortic Stenosis
Heart Lung Circ 2019; 28(9): 1310-1319
Newman JD, Alexander KP,Gu X, O’Brien SM, Boden WE, Govindan SC, Senior R, Moorthy N, Rezende PC, Demkow M, Lopez-Sendon JL, Bockeria O, Pandit N, Gosselin G, Stone PH, Spertus JA, Stone GW, Fleg JL, Hochman JS, Maron DJ. Baseline preictors of low-density lipoprotein cholesterol and systolic blood pressure goal attainment after 1 year in the ISCHEMIA trial. Circ Cardiovasc Qual Outcomes 2019; 12(11):
Vamvakidou An, Jin W, Danylenko O, Chahal N, Senior R. Low transvalvular flow rate predicts mortality in patients with low-gradient aortic stenosis following aortic valve intervention.
JACC Cardiovasc Imaging 2019; 12(9): 1715-1724
Saeed S, Vamvakidou A, Seifert R, Khattar R, Li W, Senior R
The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: A Propensity-Matched Comparison. Eur Heart J – Cardiovasc Imaging 2019; 20(10):1094-1101
Surkova E, West C, Liberty I, Flick C, Gatzoulis M, Senior R, Li, W
Added value of three-dimensional transthoracic echocardiography in assessment of an adult patient with atrioventricular septal defect. Echocardiography 2019; 36(4):809-812
Hochman J, Reynolds H, Bangalore S, O’Brien S, Alexander K, Senior R, Boden W, Stone G, Goodman S, Lopes R, Lopez-Sendon J, White W, Maggioni A, Shaw L, Min J , Picard M , Berman D ,Chaitman B , Mark D ,Spertus J , Cyr D , Bhargava B , Ruzyllo W , Wander G , Chernyavskiy A ,Rosenberg Y,Maron D.
Baseline Characteristics of Participants in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA). JAMA Cardiol 2019;4(3):273-286
Hampson R, Vamvakidou A, Kinsey C, Singh B, Senior R.
Clinical effectiveness of a sonographer-led, cardiologist-interpreted stress echocardiography service in the rapid access stable chest pain clinic. Int J Cardiol. 2019; (281):107-112
Senior R. Paving the way for improving no-reflow phenomenon. Int J Cardiol 2019; 15: 20-20
Krupickova S, Li W, Cheang MH, Rigby ML, Uebing A, Daviouros P, Dimopoulos K, Di Salvo G, Fraisse A, Swan L, Alonso-Gonzalex R, Kempny A, Pennell DJ, Senior R Gatzoulis MA, Babu-Narayan SV.
Ramipril and left ventricular diastolic function in stable patients with pulmonary regurgitation after repair of tetralogy of Fallot. Int J Cardiol 2018;
Vamvakidou A, Jin W, Danylenko O, Pradhan J, Li Li W, West C, Khattar R,
Senior R
Impact of pre-intervention transaortic flow rate versus stroke volume index on mortality across the hemodynmic spectrum of severe aortic stenosis
JACC Cardiovasc Imaging 2019; 12(1): 205-206
Toulemonde MEG, Corbett R, Papadopoulou V, Chahal N, Li Y, Leow CH, Cosgrove DO, Eckersley RJ, Dunan N, Senior R. Tang MX.
High frame-rate contrast echocardiography: In-human demonstration. JACC Cardovasc Imaging 2018; 11: 923-924.
Shah BN, MacNab A, Lynch J, Hampson R, Senior R, Steed RP; BSE Stress Accreditatopm Committee.
Stress echocardiography in contemporary clinical cardiology: practical considerations and accreditation. Echo Res Pract. 2018; 5: E1-E6
Porter TR, Mulvagh SL, Abdelmoneim SS, Becher H, Belcik JT, Bierig M, Choy J, Gaibazzi N, Gillam LD, Janardhanan R, Kutty S, Leong-Poi H, Lindner JR, Main ML, Mathias W Jr, Park MM, Senior R, Villanueva F.
Clinical applications of ultransonic enancing agents in echocardiography: 2018. ASE Guidelines update. J Am Soc Echocardiogr 2018 31: 24-274
Picard MH, Saysana K, Cyr DD, Zeng X, Scherrer-Crosbie M, Shaw LJ, Senior R, Poh KK, Bangalore S, Leipsic JA, Mancini GJ, Budoff MJ, Hague CJ, Min JK, O’Brien SM, Hochman JS, Maron DJ, Reynolds HR; ISCHEMIA Research Group.
J Am Soc Echocardiogr. 2025 Mar 18:S0894-7317(25)00150-6. doi: 10.1016/j.echo.2025.03.006. Online ahead of print.PMID: 40112959
Woodward W, Johnson CL, Krasner S, O’Driscoll J, McCourt A, Dockerill C, Balkhausen K, Chandrasekaran B, Firoozan S, Kardos A, Sabharwal N, Sarwar R, Senior R, Sharma R, Wong K, Augustine DX, Leeson P.
Eur Heart J Cardiovasc Imaging. 2025 Jan 31;26(2):187-196. https://doi.org/10.1093/ehjci/jeae291
Reynolds HR, Page CB, Shaw LJ, Berman DS, Chaitman BR, Picard MH, Kwong RY, Min JK, Leipsic J, Mancini GBJ, Budoff MJ, Hague CJ, Senior R, Szwed H, Bhargava B, Celutkiene J, Gadkari M, Bainey KR, Doerr R, Ramos RB, Ong P, Naik SR, Steg PG, Goetschalckx K, Chow BJW, Scherrer-Crosbie M, Phillips L, Mark DB, Spertus JA, Alexander KP, O’Brien SM, Boden WE, Bangalore S, Stone GW, Maron DJ, Hochman JS; ISCHEMIA Research Group.
Circ Cardiovasc Interv. 2024 Dec;17(12):e013743. https://doi.org/10.1161/CIRCINTERVENTIONS.123.013743
Myocardial Ischaemia, Not Valve Hemodynamics, Determines Prognosis in Patients with Symptomatic Moderate Aortic Stenosis
Vamvakidou, A., Hampson, R., Singh, B., Evans, J., and Senior, R.
ACC March 2025: Abstract presentation
International Variation in Health Status Benefits in Patients Undergoing Initial Invasive Versus Conservative Management for Chronic Coronary Disease: Insights From the ISCHEMIA Trial
Nobuhiro Ikemura, John A Spertus, Dan Nguyen, Zhuxuan Fu, Philip G Jones, Harmony R Reynolds, Sripal Bangalore, Balram Bhargava, Roxy Senior, Ahmed Elghamaz, Shaun G Goodman, Renato D Lopes, Radoslaw Pracoń, José López-Sendón , Aldo P Maggioni, Shun Kohsaka, Gregory A Roth, Harvey D White, Kreton Mavromatis, William E Boden, Fatima Rodriguez, Judith S Hochman, David J Maron; ISCHEMIA Research Group.
Circulation: Cardiovascular Quality and Outcomes. 2024 Oct, Vole 17 (10). https://doi.org/10.1161/CIRCOUTCOMES.123.010534
Ultrafast myocardial contrast echocardiography for the assessment of coronary artery disease: First in- human.
Gvinianidze, L., Toulemonde, M., Hampson, R., Huang, B., Bioh, G., Wakefield, L., Patel, A., Rajan, K., Tang, MX., Senior, R.
Circulation: Cardiovascular Imaging. 2024 Oct. Vol 17 (10). https://doi.org/10.1161/CIRCIMAGING.124.0172
Senior R, Khattar RS.
JACC Cardiovasc Imaging. 2024 Aug 2:S1936-878X(24)00252-3. Online ahead of print. PMID: 39152962. DOI: 10.1016/j.jcmg.2024.06.014
ESC Scientific Document Group. 2024 ESC Guidelines for the management of chronic coronary syndromes.
Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, Banning AP, Budaj A, Buechel RR, Chiariello GA, Chieffo A, Christodorescu RM, Deaton C, Doenst T, Jones HW, Kunadian V, Mehilli J, Milojevic M, Piek JJ, Pugliese F, Rubboli A, Semb AG, Senior R, Ten Berg JM, Van Belle E, Van Craenenbroeck EM, Vidal-Perez R, Winther S;
Eur Heart J. 2024 Aug 30:ehae177. doi: 10.1093/eurheartj/ehae177. Epub ahead of print. PMID: 39210710. 2024 ESC Guidelines for the management of chronic coronary syndromes – PubMed (nih.gov)
Yan, J., Huang, B., Tonko, J., Toulemonde, M., Hansen-Shearer, J., Tan, Q., Riemer, K., Ntagiantas, K., Chowdhury, R.A., Lambiase, P. D., Senior, R. and Tang, M.
Transthoracic ultrasound localization microscopy of myocardial vasculature in patients. Nat. Biomed. Eng (2024). May.
Sidik, N., McEntegart, M., Joshi, F., Owens, C., Shaukat, A., Gallagher, S., Strange, J., Tang, K., Elghamaz, A., Mozid, A., Ladwiniec, A., Oldroyd, K., Schuette, D., Copt, S., and Spratt, J.
Safety and Effectiveness of a Novel Microcatheter in Coronary Chronic Total Occlusions – The BIOMICS Study. JSCAI. 2024. May
Gvinianidze, G., Toulemonder, M., Hampson, R., Wakefield, L., Bioh, G., Tang, M. and Senior, R.
Feasibility of High Frame Rate Contrast-Enhanced Ultrasound for the Assessment of Ischaemic Heart Disease in Humans. J Am Coll Cardiol. 2024 Apr, 83 (13_Supplement) 1430.
https://doi.org/10.1016/S0735-1097(24)03420-X
Harmony Reynolds, Derek Cyr, C. Noel Bairey Merz, Leslee Shaw, Bernard Chaitman, William Boden, Karen Alexander, Yves Rosenberg, Sripal Bangalore, Gregg Stone, Claes Held, John Spertus, Kaatje Goetschalckx, Olga Bockeria, Jonathan Newman, Jeffrey Berger, Ahmed Elghamaz, Renato Lopes, James Min, Daniel Berman, Michael Picard, Raymond Kwong, Robert Harrington, Boban Thomas, Sean O’Brien, David Maron, and Judith Hochman. ISCHEMIA Research Group.
Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients with Chronic Coronary Disease: Insights from the ISCHEMIA Trial. J Am Heart Assoc. 2024;13:e029850.
https://doi.org/10.1161/JAHA.122.029850
Nobuhiro Ikemura, John Spertus, Dan Nguyen, Zhuxuan Fu, Philip Jones, Harmony Reynolds, Sripal Bangalore, Balram Bhargava, Roxy Senior, Ahmed Elghamaz, Shaun Goodman, Renato Lopes, Radoslaw Pracon, Jose Luis Lopez-Sendon, Aldo Pietro Maggioni, Shun Kohsaka, Gregory Roth, Harvey White, Kreton Mavromatis, William Boden, Fatima Rodriguez, Judith Hochman, and David Maron; ISCHEMIA Research Group.
International Variation in Health Status Benefits in Patients Undergoing Initial Invasive Versus Conservative Management for Chronic Coronary Disease: Insights from the ISCHEMIA trial. J Am Coll Cardiol. 2023 Mar, 81 (8_Supplement) 1111.
https://doi.org/10.1016/S0735-1097(23)01555-3
Bioh, G., Botrous, C. & Senior, R.
Efficacy and safety of use of ultrasound enhancing agent in patients hospitalized with COVID-19. Int J Cardiovasc Imaging (2023).
Reinette Hampson, Roxy Senior , Liam Ring, Shaun Robinson, Daniel X Augustine, Harald Becher, Natasha Anderson, James Willis, Badrinathan Chandrasekaran, Attila Kardos, Anjana Siva, Paul Leeson, Bushra Rana, Navtej Chahal, David Oxborough.
Contrast echocardiography: a practical guideline from the British Society of Echocardiography. Echo Res Pract10, 23 (2023)
Johnson CL, Woodward W, McCourt A, Dockerill C, Krasner S, Monaghan M, Senior R, Augustine DX, Paton M, O’Driscoll J, Oxborough D, Pearce K, Robinson S, Willis J, Sharma R, Tsiachristas A, Leeson P; EVAREST/BSE-NSTEP Investigators
https://doi.org/10.1186/s44156-023-00020-1
Picano E, Pierard L, Peteiro J, Djordjevic-Dikic A, Sade LE, Cortigiani L, Van De Heyning CM, Celutkiene J, Gaibazzi N, Ciampi Q, Senior R, Neskovic AN, Henein M.
https://doi.org/10.1093/ehjci/jead250
Perera D, Ryan M, Morgan HP, Greenwood JP, Petrie MC, Dodd M, Weerackody R, O’Kane PD, Masci PG, Nazir MS, Papachristidis A, Chahal N, Khattar R, Ezad SM, Kapetanakis S, Dixon LJ, De Silva K, McDiarmid AK, Marber MS, McDonagh T, McCann GP, Clayton TC, Senior R, Chiribiri A; REVIVED-BCIS2 Investigators.
Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction: A Prespecified Secondary Analysis of the REVIVED-BCIS2 Trial. JAMA Cardiol. 2023 Oct 25
doi:10.1001/jamacardio.2023.3803
Davis EF, Crousillat DR, Peteiro J, Lopez-Sendon J, Senior R, et al CIAO-ISCHEMIA Research Group.
Global Longitudinal Strain as Predictor of Inducible Ischaemia in No Obstructive Coronary Artery Disease in the CIAO-ISCHEMIA Study. J AM Soc Echocardiography (2023) 37(1) 89-99
Gurunathan S, Shanmuganathan S, Chopra A, Pradhan J, Aboud L,Hampson R, Yakupoglu Y, Bioh G, Banfield A, Gage H,Khattar, Senior R
Comparative Effectiveness of Exercise Electrocardiography Versus Exercise Echocardiography in Women Presenting with Suspected Coronary Artery Disease: A Randomised Study. Eur Heart J Open. 2023 May 22;3(3).
Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O’Brien SM, Boden WE, Chaitman BR, Senior R, López-Sendón J, Alexander KP, Lopes RD, Shaw LJ, Berger JS, Newman JD, Sidhu MS, Goodman SG, Ruzyllo W, Gosselin G, Maggioni AP, White HD, Bhargava B, Min JK, Mancini GBJ, Berman DS, Picard MH, Kwong RY, Ali ZA, Mark DB, Spertus JA, Krishnan MN, Elghamaz A, Moorthy N, Hueb WA, Demkow M, Mavromatis K, Bockeria O, Peteiro J, Miller TD, Szwed H, Doerr R, Keltai M, Selvanayagam JB, Steg PG, Held C, Kohsaka S, Mavromichalis S, Kirby R, Jeffries NO, Harrell FE Jr, Rockhold FW, Broderick S, Ferguson TB Jr, Williams DO, Harrington RA, Stone GW, Rosenberg Y; ISCHEMIA Research Group.
Initiall Invasive or Conservative Strategy for Stable Coronary Disease. N Engl J Med. 2020 Apr 9;382(15):1395-1407.
Fusco F, Shimada E, Scognamiglio G, Senior R, Gatzoulis MA, Babu-Narayan S, Li W. Restrictive ventricular septal defect resulting in systemic outflow obstruction in adults with Fontan circulation. Challenging diagnosis of a serious and potentially fatal complication.
J Cardiovasc Med 2020; 21(3): 276-279
Mushemi-Blake S, Surkova E, Hatipoqlu S, Senior R, Li W. Severe regurgitation of a double-orifice left atrioventricular valve in a patient with repaired atrioventricular septal defect: Added value of 3D echocardiography. Eur Heart J Cardiovasc Imaging 2020; 21(7): 814
Ahmadvazir S, Pradhan J, Khattar RS, Senior R. Long-Term Prognostic Value of Simultaneous Assessment of Atherosclerosis and Ischemia in Patients with Suspected Angina: Implications for Routine Use of Carotid Ultrasound During Stress Echocardiography
J Am Soc Echocardiogr 2020;33(5):559-569
Halliday B, Senior R, Pennell D
Assessing left ventricular systolic function – from ejection fraction to strain analysis
Eur Heart J 2020
Chahal N, Senior
Assessing Systolic Function In Aortic Stenosis: The Earlier The Better?
Heart 2020;106(16):1200-1201
Ahmadvazir S, Pradhan J, Khattar RS, Senior R
Sex-based impact of carotid plaque in patients with chest pain undergoing stress echocardiography. Heart 2020
Nam MCY, Meneses ML, Byrne CD, Richman T, Quah JX, Bailey TG, Hickman I, Anstey C, Askew CD, Senior R, Stanton T, Russell AW, Greave K. An experimental series investigating the effects of hyperinsulinemic euglycemia on myocardial blood flow reserve in healthy individuals and on myocardial perfusion defect size following st-segment elevation myocardial infarction. J Am Soc Echocardiogr 2020; ; 33:868
Reynold HR, Shaw LJ, Min JK, Spertus JA, Chaitman BR, Berman DS, Picard MH, Kwong RY, Bairey-Nerz CN, Cyr DD, Lopes DD, Lopez- Sendon JL, Held C, Szwed H, Senior R, Gosselin G, Nair R, Elghamaz A, Bockeria O, Chen J, Chemyavskiy AM, Bhargava B, Newman JD, Hinic SB, Jaroch J, Hoye A, Berger J, Boden WE, O’Brien SM, Maron DJ, Ischemia Research Group.
Association of sex with severity of coronary artery disease, ischemia, and symptom burden in patients with moderate or severe ischemia: secondary analysis of the ischemia randomized clinical trial. JAMA Cardiol. 2020 Jul 1;5(7):773-786
Dewey M, Siebes M, Kachelrieß M, Kofoed KF, Maurovich-Horvat P, Nikolaou K, Bai W, Kofler A, Manka R, Kozerke S, Chiribiri A, Schaeffter T, Michallek F, Bengel F, Nekolla S, Knaapen P, Lubberink M, Senior R, Tang MX, Piek JJ, van de Hoef T, Martens J, Schreiber L; Quantitative Cardiac Imaging Study Group.
Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia.
Nat Rev Cardiol 2020;17(7):427-450
Bioh G, Senior R.
Stress echocardiography in the era of fractional flow reserve
Current Cardiovascular Imaging Reports 2020; 13(6)
Danylenko O, Surkova E, Senior R, Li W
Unexpected mechanism of mitral regurgitation in a patient post ALCAPA repair: Added value of three-dimensional echocardiography
Echocardiography 2020; 37: 1315-1317
Senior R, Khattar RS
Assessment of aortic stenosis: Time to go with the flow
Editorial Coment: J Am Coll Cardiol 2020; 75 (15): 1770-1771
Radhakrishnan A, Price AM, Pickup LC, Law JP, McGee KC, Fabritz L, Senior R, Steeds RP, Ferro CJ, Townend JN
Coronary flow velocity reserve and inflammatory markers in living kidney donors
Int J Cardiol 2020 (in press)
Yakupoglu HY, Saeed S, Senior R, Baksi AJ, Lyon AR, Khattar RS. Reversible exercise induced left ventricular dysfunction in symptomatic patients with previous Takotsubosyndrome: insights from stress echocardiography.
Eur Heart J Cardiovasc Imaging. 2020 Sep 18: jeaa237. doi: 10.1093/ehjci/jeaa237. Online ahead of print
Gurunathan S, Shanmuganathan M, Hampson R, Khattar R, Senior R.
Role of adjuvant carotid ultrasound in women undergoing stress echocardiography for the assessment of suspected coronary artery disease.
Open Heart 2020 (in press)
Hochman JS, Reynolds HR, Bangalore S, O’Brien SM, Alexander KP, Senior R, Boden WE, Stone GW, Goodman SG, Lopes RD, Lopez-Sendon J, White HD, Maggioni AP, Shaw LJ, Min JK, Picard MH, Berman DS, Chaitman BR, Mark DB, Spertus JA, Cyr DD, Bhargava B, Ruzyllo W, Wander GS, Chernyavskiy AM, Rosenberg YD, Maron DJ; ISCHEMIA Research Group
Baseline Characterstics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial
JAMA Cardiol 2019; 4(3): 273-286
Chong A, Senior R, Wahi S.
Contemporary Imaging of Aortic Stenosis
Heart Lung Circ 2019; 28(9): 1310-1319
Newman JD, Alexander KP,Gu X, O’Brien SM, Boden WE, Govindan SC, Senior R, Moorthy N, Rezende PC, Demkow M, Lopez-Sendon JL, Bockeria O, Pandit N, Gosselin G, Stone PH, Spertus JA, Stone GW, Fleg JL, Hochman JS, Maron DJ. Baseline preictors of low-density lipoprotein cholesterol and systolic blood pressure goal attainment after 1 year in the ISCHEMIA trial. Circ Cardiovasc Qual Outcomes 2019; 12(11):
Vamvakidou An, Jin W, Danylenko O, Chahal N, Senior R. Low transvalvular flow rate predicts mortality in patients with low-gradient aortic stenosis following aortic valve intervention.
JACC Cardiovasc Imaging 2019; 12(9): 1715-1724
Saeed S, Vamvakidou A, Seifert R, Khattar R, Li W, Senior R
The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: A Propensity-Matched Comparison. Eur Heart J – Cardiovasc Imaging 2019; 20(10):1094-1101
Surkova E, West C, Liberty I, Flick C, Gatzoulis M, Senior R, Li, W
Added value of three-dimensional transthoracic echocardiography in assessment of an adult patient with atrioventricular septal defect. Echocardiography 2019; 36(4):809-812
Hochman J, Reynolds H, Bangalore S, O’Brien S, Alexander K, Senior R, Boden W, Stone G, Goodman S, Lopes R, Lopez-Sendon J, White W, Maggioni A, Shaw L, Min J , Picard M , Berman D ,Chaitman B , Mark D ,Spertus J , Cyr D , Bhargava B , Ruzyllo W , Wander G , Chernyavskiy A ,Rosenberg Y,Maron D.
Baseline Characteristics of Participants in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA). JAMA Cardiol 2019;4(3):273-286
Hampson R, Vamvakidou A, Kinsey C, Singh B, Senior R.
Clinical effectiveness of a sonographer-led, cardiologist-interpreted stress echocardiography service in the rapid access stable chest pain clinic. Int J Cardiol. 2019; (281):107-112
Senior R. Paving the way for improving no-reflow phenomenon. Int J Cardiol 2019; 15: 20-20
Krupickova S, Li W, Cheang MH, Rigby ML, Uebing A, Daviouros P, Dimopoulos K, Di Salvo G, Fraisse A, Swan L, Alonso-Gonzalex R, Kempny A, Pennell DJ, Senior R Gatzoulis MA, Babu-Narayan SV.
Ramipril and left ventricular diastolic function in stable patients with pulmonary regurgitation after repair of tetralogy of Fallot. Int J Cardiol 2018;
Vamvakidou A, Jin W, Danylenko O, Pradhan J, Li Li W, West C, Khattar R,
Senior R
Impact of pre-intervention transaortic flow rate versus stroke volume index on mortality across the hemodynmic spectrum of severe aortic stenosis
JACC Cardiovasc Imaging 2019; 12(1): 205-206
Toulemonde MEG, Corbett R, Papadopoulou V, Chahal N, Li Y, Leow CH, Cosgrove DO, Eckersley RJ, Dunan N, Senior R. Tang MX.
High frame-rate contrast echocardiography: In-human demonstration. JACC Cardovasc Imaging 2018; 11: 923-924.
Shah BN, MacNab A, Lynch J, Hampson R, Senior R, Steed RP; BSE Stress Accreditatopm Committee.
Stress echocardiography in contemporary clinical cardiology: practical considerations and accreditation. Echo Res Pract. 2018; 5: E1-E6
Porter TR, Mulvagh SL, Abdelmoneim SS, Becher H, Belcik JT, Bierig M, Choy J, Gaibazzi N, Gillam LD, Janardhanan R, Kutty S, Leong-Poi H, Lindner JR, Main ML, Mathias W Jr, Park MM, Senior R, Villanueva F.
Clinical applications of ultransonic enancing agents in echocardiography: 2018. ASE Guidelines update. J Am Soc Echocardiogr 2018 31: 24-274