Take part in heart research

There are several ways to take part in heart research and it can be very rewarding. It gives you a chance to help others, as well as getting specialist care yourself for the duration of the trial. Many of our patients are sorry when a trial comes to and end, and frequently sign up to do another one if they fit the criteria!

Academic Projects

There are several ways you can take part in heart research. We currently have two research fellows working in our department,  who have the opportunity to carry out their MD projects. Our current project is looking at how Covid-19 affects the heart. We are asking patients who have been admitted to hospital with Covid-19 and need a heart ultrasound scan (echocardiogram) to take part. The data from their scan and blood test results from their admission are analysed. They are then asked to attend for a second scan 6 months after they have gone home.

Want to take part in heart research in Harrow?

Our projects and trials are listed below. If you would like to volunteer for a trial or find out more information, please click on the ‘Find out how to volunteer’ button, You can also drop us an email or use the contact form on our Get in Touch page.

Ethical Approval

No research can take place in the hospital with out it going through a review process. To start a project you need approval from  the National Research Ethics Service (NRES) and the Health Research Authority (HRA). You also need permission from the Research and Development Department in the NHS Trust. Medicine trials also need approval from the MHRA. Trials that use any radiation such as CT scans, x-rays or angiograms, also need special permission.

All our staff undertake Good Clinical Practice training to ensure that the research is carried to the highest standard. We always have the patient’s best interests at heart. 

Many of our patients enjoy taking part in research and have taken part in several different projects over the years.

I would though, like to take this opportunity to praise the staff that I came into contact with during my involvement in the Cardiac Trials.  During my time on the trials, I was treated with nothing but respect, kindness, care and good humour. I was always given the fullest of information before taking part, and then treated with the utmost care and consideration at all times.

POSEIDON

We are really excited to be able to offer our patient with known heart disease the chance of taking part in this simple study. We know there is a link between inflammation and heart disease and this study will help us to understand how common the problem is. If you agree to take part you will have a few basic measurements taken, like your height, weight and blood pressure, followed by a quick blood test to look for imflammation. There is no follow-up for the study, so you will just have a one-off visit of around half an hour.

If you are a LNWH patient with heart disease interested in taking part in this study we would love to hear from you! Please get in touch by clicking the button below. 

VICTORION-1 PREVENT

This study is sponsored by Novartis Pharmaceuticals. It is looking at a new treatment to prevent cardiovascular events (for example heart attacks and strokes) in people who have never had one before but who have high cholesterol.

14,000 patients from around the world are taking part. Patients who choose to take part in this study will either receive a 6-monthly injection of a medicine called inclisiran or placebo as well as their usual medicines. Neither the patient or Doctor will know which they are taking.

The study will last about 4 years and during that time you will regular be seen by the cardiologist and specialised research practitioners as part of your care.

If you are a LNWH patient with heart disease interested in taking part in this study we would love to hear from you! Please get in touch by clicking the button below.  

EVAREST

Patients who are attending the department for a stress echocardiogram are being asked if they would be interested in taking part in this trial. It involves giving consent to having your images and some data transferred to Oxford University. Here, they will be added to the existing database to help create artificial intelligence for interpreting the scans. You will also be called after 12 months to see if you have had any health problems during this time. There are no extra visits associated with taking part in this valuable research project. 

EZDB

There are currently millions of patients who suffer from heart failure. This study is inviting 432 patients from around the world to take part. The study is looking at whether a medication called Relaxin-LA improves symptoms for some patients with heart failure. If you agree to take part, you will take either Relaxin-LA or Placebo as well as your usual medicines. Neither your or your Doctor will know which medicine you are taking. The study will last 32 weeks.

Unfortunately you cannot volunteer for this study, but the research team will contact you if they think you might be suitable to see if you would be interested in taking part.

 

NAGOMI

To take part in this study doesn’t involve taking any new tablets or coming back into the hospital for any research visits.

If you are coming into Northwick Park Hospital for an angiogram and a NAGOMI ultimaster stent is used as part of your usual care, we will ask you if you would be happy for us to collect data from your medical record and call you every 6-months’ to see how you are feeling.

You canot volunteer for this study, but we will come and find you in the hospital if we think you might be able to take part.

RUFUS – heart

We have now started recruiting into this exciting trial! This high frame rate project is being run with the department of biomedical engineering at Imperial College London. Eligible patients are those who have has a stress echocardiogram which was positive.  As a result of this, they have been referred for an angiogram. The study lasts one day and you will have a series of scans to look at the heart. These will be both at normal ultrasound frequency and high ultrasound  frequency. If this pilot study is successful, we will be looking to undertake a larger trial.

Covid – Echo

The final analysis is now being carried out on this data and we are really grateful for those that have taken part. We hope to have published the results soon, and when we have we will put the link here for those that are interested. 

Prevalence of cardiac pathology and relation to mortality in a multiethnic population hospitalised with COVID-19

Hi Peitho

This study is looking at the best way to treat patients who are admitted to hospital with a blood clot in an artery that leads to the lung. When this happens the blood supply to the lung is blocked. We are seeing is treatment to dissolve this blood clot using a special device and ultrasound is better than just giving the treatment without the aid of ultrasound.

To take part, patients must fit certain criteria and of course be happy to do so. They will have been admitted to hospital with this condition and will be followed up by the study team once they have gone home. Patients take part in this study will be randomly allocated to which treatment they get. In this way we make sure the results are as accurate as possible and the study team can’t bias the results.

Garden-TIMI 74

We have just started inviting patients with heart failure to take part in this new study. The study is looking to see if it is possible to reduce the symptoms patients with heart failure experience, such as breathlessness, tiredness, reduced apetite and weight loss. Patients who choose to take part in this study will either take a medicine called ponsegromab or placebo as well as their usual medicines. Neither the patient or Doctor will know which they are taking.  Patients will come to the hospital every 4 weeks to take their study medication and the study will last up to 32 weeks in total.

If you are a LNWH patient with heart failure interested in taking part in this study we would love to hear from you! Please get in touch by clicking the button below. 

 

Horizon

This study is sponsored by Novartis Pharmaceuticals. It is looking at a new treatment for people who have a raised level of a particle found in the blood called lipoprotein (a). Raised levels of this particle is thought to increase your risk of hardening of the arteries. Having an increased level of this is genetic, rather than anything to do with your lifestyle.

People who already have heart disease are being asked to take part in this study. They will be eligible if a blood test shows that they have increased amounts of Lp(a).  The study will last about 4 years and during that time you will regular be seen by the cardiologist and specialised research practitioner as part of your care.

Recruitment has now ended for this study and those taking part continue to be followed up. 

Future studies

We have several studies in set up at the moment. They will be looking at conditions such as heart failure, coronary artery disease and heart imaging. If you are interested in finding out more or taking part in any of our research studies please contact us on the link below.