Take part in heart research

There are several ways to take part in heart research and it can be very rewarding. It gives you a chance to help others, as well as getting specialist care yourself for the duration of the trial. Many of our patients are sorry when a trial comes to and end, and frequently sign up to do another one if they fit the criteria!

Academic Projects

There are several ways you can take part in heart research. We currently have two research fellows working in our department,  who have the opportunity to carry out their MD projects. Our current project is looking at how Covid-19 affects the heart. We are asking patients who have been admitted to hospital with Covid-19 and need a heart ultrasound scan (echocardiogram) to take part. The data from their scan and blood test results from their admission are analysed. They are then asked to attend for a second scan 6 months after they have gone home.

Want to take part in heart research in Harrow?

Our projects and trials are listed below. If you would like to volunteer for a trial or find out more information, please click on the ‘Find out how to volunteer’ button, You can also drop us an email or use the contact form on our Get in Touch page.

Ethical Approval

No research can take place in the hospital with out it going through a review process. To start a project you need approval from  the National Research Ethics Service (NRES) and the Health Research Authority (HRA). You also need permission from the Research and Development Department in the NHS Trust. Medicine trials also need approval from the MHRA. Trials that use any radiation such as CT scans, x-rays or angiograms, also need special permission.

All our staff undertake Good Clinical Practice training to ensure that the research is carried to the highest standard. We always have the patient’s best interests at heart. 

Many of our patients enjoy taking part in research and have taken part in several different projects over the years.

I would though, like to take this opportunity to praise the staff that I came into contact with during my involvement in the Cardiac Trials.  During my time on the trials, I was treated with nothing but respect, kindness, care and good humour. I was always given the fullest of information before taking part, and then treated with the utmost care and consideration at all times.

DAPA-MI

We are really excited to be able to offer our patients the chance of taking part in this trial. Dapagliflozin is a medicine that belong to a group called SGLT2 inhibitors. It was first used in patients who had diabetes, but further research has shown it may help patients who are at risk of developing heart failure after a heart attack.This trial is being carried out in the UK and Sweden. If you agree to take part you will receive either dapagliflozin or a dummy tablet as well as your usual medicines. Neither you or your doctor will know what you are taking. You will be followed up by the specialist study team for the duration of the study, which will be around 2-3 years.

Horizon

This study is sponsored by Novartis Pharmaceuticals. It is looking at a new treatment for people who have a raised level of a particle found in the blood called lipoprotein (a). Raised levels of this particle is thought to increase your risk of hardening of the arteries. Having an increased level of this is genetic, rather than anything to do with your lifestyle.

People who already have heart disease are being asked to take part in this study. They will be eligible if a blood test shows that they have increased amounts of Lp(a).  The study will last about 4 years and during that time you will regular be seen by the cardiologist and specialised research practitioner as part of your care.

If you are interested, please get in touch.

EVAREST

Patients who are attending the department for a stress echocardiogram are being asked if they would be interested in taking part in this trial. It involves giving consent to having your images and some data transferred to Oxford University. Here, they will be added to the existing database to help create artificial intelligence for interpreting the scans. You will also be called after 12 months to see if you have had any health problems during this time. There are no extra visits associated with taking part in this valuable research project.

SELECT TRIAL

Unfortunately, recruitment for this study is now closed, although patients who have agreed to take part in the trial continue to do so.  We will continue to give support throughout the trial as to how to live a healthier life style and the follow up study visits will continue with Emma and Gabriel.

Care-HK HF

To take part in this study doesn’t involve taking any new tablets. We want to learn more about how people with heart failure are treated in real life. Treating heart failure often involves balancing the different medications, but some medications can affect the amount of potassium found in the blood. We want to learn about how this changes the treatment you are on.

Taking part in the study involves to completing a series of questionnaires every 6 months for 2-4 years. One of the study coordinators will telephone you about this, or it can be done by email if you prefer. 

If you are a LNWH patient and are interested in this study, we would love to hear from you! Please get in touch with us using the button below. 

High Frame rate Ultrasound

We have now started recruiting into this exciting trial! This high frame rate project is being run with the department of biomedical engineering at Imperial College London. Eligible patients are those who have has a stress echocardiogram which was positive.  As a result of this, they have been referred for an angiogram. The study lasts one day and you will have a series of scans to look at the heart. These will be both at normal ultrasound frequency and high ultrasound  frequency. If this pilot study is successful, we will be looking to undertake a larger trial.

Covid – Echo

We have now started to invite the patients back to the department who kindly agreed to take part in this study. While in hospital with COVID-19, they kindly agreed to help with research. We did an initial ultrasound scan while they were in hospital. We will  now do a second scan to see if there are any changes. One paper has already been published from this research.

Prevalence of cardiac pathology and relation to mortality in a multiethnic population hospitalised with COVID-19

Hi Peitho

Patients eligible for this study will have been admitted to hospital with a pulmonary embolism (blood clot in the lung). If they meet the criteria for this study they will be asked if they would be happy to take part. If they agree, they will be randomised (randomly allocated) to one of 2 groups. One group will be treated with blood thinners and ultrasound and the other or blood thinners alone.

While the ultrasound system is fully licensed and in daily use, we do not yet know if it makes a difference to people you have it in the long term This study hopes to answer this question.